Recyclable positive azeotropes for the purification of curcumin with optimum purity and solvent capacity was written by Tseng, Jia De;Lee, Hung Lin;Yeh, Kuan Lin;Lee, Tu. And the article was included in Chemical Engineering Research and Design in 2022.Formula: C19H16O4 The following contents are mentioned in the article:
Purification of curcumin (CUR) from crude CUR, which is referred to as curcuminoids, has been conducted by cooling crystallization with the use of two azeotropes of Et acetate/ethanol (AZE-EA/EtOH) and Et acetate/isopropyl alc. (AZE-EA/IPA), as compared to the use of single solvents, including acetone, EA, EtOH, and IPA. According to the determination of crude CUR solubility in those solvents, the effects of stirring, crystallization time, and seeding on the induction time, purity, and yield of CUR product were investigated on a small scale. Especially the effects of the purity of CUR seed crystals have a pos. trend on the CUR purity. Seeding at a high temperature is suggested. The use of AZE-EA/EtOH shows the optimum purity of 94.0% and solvent capacity of 16.0 mg/mL with a yield of 29.0% by seeded cooling crystallization in a single step. Similar results are observed in the larger scale purification of CUR with a higher purity of 94.9%. After purification, the azeotropes can easily be recovered for reuse without changing their compositions, confirmed by GC, d., and b.p. determination This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem