Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo/leucoderma was written by Shivasaraun, U. V.;Sureshkumar, Raman;Karthika, Chenmala;Puttappa, Nethravathi. And the article was included in Medical Hypotheses in 2018.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
Vitiligo is a disorder characterized by the decrease in melanin pigment of skin. This depigmenting disorder has prevalence among worldwide, irresp. of age and sex. There is an existence of different treatment modalities for the management of vitiligo. But irresp. of treatment methods, the main drawback in the management of vitiligo is the occurrence of side effects during the implication of treatment. Among the treatment modalities, photochemotherapy seems to be the better choice of treatment for vitiligo. Photochemotherapy involves the usage of UV rays for photoactivation of the drug to cause photosensitization of skin which in turn leads to repigmentation. The main aim of the study is to develop novel combination strategy of lipid based nanoemulsion gel for the treatment of leucoderma using trimethylpsoralen and flavonoid. We assume that if this hypothesis of combination therapy proves successful it can be used as an addnl. novel treatment strategy in the management of vitiligo. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem