Antioxidant and Biological Activities of Hydroxytyrosol and Homovanillic Alcohol Obtained from Olive Mill Wastewaters of Extra-Virgin Olive Oil Production was written by Ricelli, Alessandra;Gionfra, Fabio;Percario, Zulema;De Angelis, Martina;Primitivo, Ludovica;Bonfantini, Veronica;Antonioletti, Roberto;Bullitta, Simonetta Maria;Saso, Luciano;Incerpi, Sandra;Pedersen, Jens Zacho. And the article was included in Journal of Agricultural and Food Chemistry in 2020.Synthetic Route of C9H12O3 The following contents are mentioned in the article:
Some constituents of the Mediterranean diet, such as extra-virgin olive oil (EVOO) contain substances such as hydroxytyrosol (HT) and its metabolite homovanillic alc. (HA). HT has aroused much interest due to its antioxidant activity as a radical scavenger, whereas only a few studies have been made on the HA mol. Both chem. synthesis and extraction techniques have been developed to obtain these mols., with each method having its advantages and drawbacks. In this study, we report the use of tyrosol from olive mill wastewaters as a starting mol. to synthesize HT and HA, using a sustainable procedure characterized by high efficiency and low cost. The effects of HT and HA were evaluated on two cell lines, THP-1 human leukemic monocytes and L-6 myoblasts from rat skeletal muscle, after treating the cells with a radical generator. Both HT and HA efficiently inhibited ROS production In particular, HT inhibited the proliferation of the THP-1 leukemic monocytes, while HA protected L-6 myoblasts from cytotoxicity. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C9H12O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem