Design, synthesis and cytotoxicity evalufation of substituted benzimidazole conjugated 1,3,4-oxadiazoles was written by Quy, Nguyen Phu;Hue, Bui Thi Buu;Do, Kiep Minh;Quy, Ha Thi Kim;De, Tran Quang;Phuong, Tran Thi Bich;Trang, Pham Cong;Quoc, Nguyen Cuong;Morita, Hiroyuki. And the article was included in Chemical & Pharmaceutical Bulletin in 2022.Application of 109-85-3 The following contents are mentioned in the article:
Two series of 2-substituted benzimidazole conjugated 1,3,4-oxadiazole derivatives were designed, synthesized and evaluated for their cytotoxic activities against the three human cancer cell lines (cervical cancer (HeLa), breast cancer (MCF-7) and lung cancer (A549)). As the results 14 compounds demonstrated consistent to stronger cytotoxicities compared to the control 5-fluorouracil (5-FU) towards the tested cell lines including 4c (HeLa); 4b, 4e, 4h, 7i-j, 7m-n, 7s (MCF-7); 7b (MCF-7, A549); 7h (HeLa, MCF-7); and 4d, 4i, 7c (HeLa, MCF-7, A549), with the IC50 ranging from 2.7 to 38 μM. Notably, compound 4b illustrated almost 5-fold activity against the MCF-7 while 4d, 4i were 9- and 8-fold (HeLa), 4.5- and 13-fold (MCF-7), 4.7- and 4-fold (A549) increase in activity compared to 5-FU, resp., and were found as lead compounds These findings suggest that compounds 4b, 4d and 4i merit further characterization and can serve as promising scaffolds in the discovery of new potent anticancer agents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem