Synthesis of new substituted (2H-chromen-2-one)-phenol derivatives: An approach to molecular docking and antimicrobial assession was written by Mangasuli, Sumitra N.;Managutti, Praveen B.;Hosamani, Kallappa M.;Joshi, Shrinivas D.. And the article was included in Chemical Data Collections in 2020.Quality Control of 4-Benzyloxyphenol The following contents are mentioned in the article:
A number of new substituted (2H-chromen-2-one)-phenol derivatives I [R = Me, Cl, Br, etc.] were synthesized by Williamson ether reaction follows an SN2 bimol. nucleophilic substitution mechanism. The titled compounds I was characterized by IR, 1H NMR, 13C NMR and Mass spectral studies. As predicted, the derivatization of benzyloxy phenol with coumarin via ether linkage enhanced the activity of the titled compounds I against four bacterial and four fungal strains. Compound I [R = 1-naphthyloxy] showed significant strong anti-microbial broad spectrum activity against all tested bacterial and fungal strains. Anti-bacterial assay against standard coupled with in-silico mol. docking studies indicated that I [R = 1-naphthyloxy] showed promising activity with higher C-score values. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Quality Control of 4-Benzyloxyphenol).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 4-Benzyloxyphenol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem