Synthesis of new substituted (2H-chromen-2-one)-phenol derivatives: An approach to molecular docking and antimicrobial assession was written by Mangasuli, Sumitra N.;Managutti, Praveen B.;Hosamani, Kallappa M.;Joshi, Shrinivas D.. And the article was included in Chemical Data Collections in 2020.Application of 103-16-2 The following contents are mentioned in the article:
A number of new substituted (2H-chromen-2-one)-phenol derivatives I [R = Me, Cl, Br, etc.] were synthesized by Williamson ether reaction follows an SN2 bimol. nucleophilic substitution mechanism. The titled compounds I was characterized by IR, 1H NMR, 13C NMR and Mass spectral studies. As predicted, the derivatization of benzyloxy phenol with coumarin via ether linkage enhanced the activity of the titled compounds I against four bacterial and four fungal strains. Compound I [R = 1-naphthyloxy] showed significant strong anti-microbial broad spectrum activity against all tested bacterial and fungal strains. Anti-bacterial assay against standard coupled with in-silico mol. docking studies indicated that I [R = 1-naphthyloxy] showed promising activity with higher C-score values. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 103-16-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem