Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis was written by Mahmud, Hafij Al;Seo, Hoonhee;Kim, Sukyung;Islam, Imtiazul Md;Sultana, Omme Fatema;Nam, Kung-Woo;Lee, Byung-Eui;Sadu, Venkata S.;Lee, Kee-In;Song, Ho-Yeon. And the article was included in Future Medicinal Chemistry in 2021.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Initially, 2- nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 μg/mL). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem