Tert-Butyl Hydroperoxide Promoted the Reaction of Quinazoline-3-oxides with Primary Amines Affording Quinazolin-4(3H)-ones was written by Luo, Jin;Wan, Juelin;Wu, Lianlian;Yang, Lingyun;Wang, Tao. And the article was included in Journal of Organic Chemistry in 2022.Name: 2-Methoxyethylamine The following contents are mentioned in the article:
An efficient and facile approach for the synthesis of quinazolin-4(3H)-ones I [R1 = C6H5, 2-MeC6H4, 4-MeC6H4, 2-furyl, n-Pr, etc., R2 = R3 = H; R1 = Ph, R2 = H, 7-OMe, 6,7-(OMe)2, 6-F, etc., R3 = H, Me] via the reaction of quinazoline-3-oxides II with primary amines R1CH2Ph is described. This approach was demonstrated to be applicable for a broad range of substrates and proceeds efficiently under metal-free and mild reaction conditions employing easily available tert-Bu hydroperoxide as the oxidant. Remarkably, I [R1 = 1H-indol-3-ylmethyl], which was conveniently obtained by this process in 70% yield, was an excellent precursor for the synthesis of bioactive evodiamine and rutaecarpine. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: 2-Methoxyethylamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem