A novel N-nitrosation-based ratiometric fluorescent probe for highly selective imaging endogenous nitric oxide in living cells and zebrafish was written by Liu, Peilian;Li, Bowen;Zheng, Jian;Liang, Qiqi;Wu, Cailing;Huang, Liping;Zhang, Peisheng;Jia, Yongmei;Wang, Sheng. And the article was included in Sensors and Actuators, B: Chemical in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:
Nitric oxide (NO), a widespread signaling transduction mol. in organism, plays key roles in lots of pathophysiol. processes. Aberrant level of NO is closely related to tumors, cardiovascular and cerebrovascular diseases, neurodegenerative diseases and many other diseases. Therefore, sensing NO in cells and in vivo is of great significance for the study of the chem. biol. of related diseases. Herein, a novel ratiometric fluorescence probe (AC-SA), in which anthracene carboximide used as fluorophore and secondary amines at the 6th position of the fluorophore severed as recognition moiety is rationally designed to detect NO. The AC-SA can capture NO via N-nitrosation reaction to give obvious fluorescence signal change from red to green based on the intramol. charge transfer (ICT) mechanism. The AC-SA features striking ratiometric signal (I525/I625), good sensitivity (4.05 nM), high selectivity for sensing NO over various interferents in physiol. pH. More important, the AC-SA can be applied to image endogenous NO in Raw 264.7 macrophage cells as well as zebrafish in a ratiometric manner. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem