Lipid-Oriented Live-Cell Distinction of B and T Lymphocytes was written by Kwon, Haw-Young;Kumar Das, Raj;Jung, Gun Tae;Lee, Hong-Guen;Lee, Sun Hyeok;Berry, Stuart N.;Tan, Justin Kok Soon;Park, Solip;Yang, Jae-Seong;Park, Soohyun;Baek, Kangkyun;Park, Kyeng Min;Lee, Jae Won;Choi, Yun-Kyu;Kim, Ki Hean;Kim, Sangho;Kim, Kwang Pyo;Kang, Nam-Young;Kim, Kimoon;Chang, Young-Tae. And the article was included in Journal of the American Chemical Society in 2021.Product Details of 109-85-3 The following contents are mentioned in the article:
The identification of each cell type is essential for understanding multicellular communities. Antibodies set as biomarkers have been the main toolbox for cell-type recognition, and chem. probes are emerging surrogates. Herein we report the first small-mol. probe, CDgB, to discriminate B lymphocytes from T lymphocytes, which was previously impossible without the help of antibodies. Through the study of the origin of cell specificity, we discovered an unexpected novel mechanism of membrane-oriented live-cell distinction. B cells maintain higher flexibility in their cell membrane than T cells and accumulate the lipid-like probe CDgB more preferably. Because B and T cells share common ancestors, we tracked the cell membrane changes of the progenitor cells and disclosed the dynamic reorganization of the membrane properties over the lymphocyte differentiation progress. This study casts an orthogonal strategy for the small-mol. cell identifier and enriches the toolbox for live-cell distinction from complex cell communities. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem