Mechanism of action of 4-substituted phenols to induce vitiligo and antimelanoma immunity was written by Kammeyer, Arthur;Willemsen, Karin J.;Ouwerkerk, Wouter;Bakker, Walbert J.;Ratsma, Danielle;Pronk, Sebas D.;Smit, Nico P. M.;Luiten, Rosalie M.. And the article was included in Pigment Cell & Melanoma Research in 2019.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:
Monobenzone is a 4-substituted phenol that can induce vitiligo and antimelanoma immunity. We investigated the influence of the chem. structure on the biol. activity of a series of structurally related 4-substituted phenols. All phenols inhibited cellular melanin synthesis, and eight of ten phenols inhibited tyrosinase activity, using the MBTH assay. These phenols also induced glutathione (GSH) depletion, indicative of quinone formation and protein thiol binding, which can increase the immunogenicity of melanosomal proteins. Specific T-cell activation was found upon stimulation with phenol-exposed pigmented cells, which also reacted with unexposed cells. In contrast, 4-tertbutylphenol induced immune activation was not restricted to pigment cells, analogous to contact sensitization. We conclude that 4-substituted phenols can induce specific T-cell responses against melanocytes and melanoma cells, also acting at distant, unexposed body sites, and may confer a risk of chem. vitiligo. Conversely, these phenols may be applicable to induce specific antimelanoma immunity. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 103-16-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem