Asymmetric Synthesis of 3-Pyrrolines through an Aryne-Induced Domino Process was written by Hwu, Jih Ru;Panja, Avijit;Gupta, Nitesh K.;Huang, Wen-Chieh;Hu, Yu-Chen;Lin, Chun-Cheng;Hwang, Kuo-Chu;Chan, Wei-Jen;Tsay, Shwu-Chen. And the article was included in Asian Journal of Organic Chemistry in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:
Here, the accomplishment of a newly developed domino reaction was reported for synthesizing optically active 3-pyrrolines I [R1 = H, OMe, OCH2O; R2 = H, p-Me, p-OMe, m-Br; R3 = OMe, CN, CO2Me; R4 = CO2Me, CO2Et; R5 = H, CO2Me, CO2Et], a class of compounds with various biol. properties. The reaction involved the use of (trimethylsilyl)aryl triflates, Schiff bases, and alkynes in the presence of a chiral catalyst (R)-(-)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate. The key features of this new reaction include the generation of a single product in very good yields (75-85%) with high stereo- and enantio-selectivity; the enantiomeric ratio reaches as high as 98.5 : 1.5. Moreover, it involved an aryne-induced domino reaction and an unusual 1,4-intramol. proton transfer, which overwhelms the well-established 1,5-proton transfer. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem