Efficient asymmetric biomimetic aldol reaction of glycinates and trifluoromethyl ketones by carbonyl catalysis was written by Cheng, Aolin;Zhang, Liangliang;Zhou, Qinghai;Liu, Tao;Cao, Jing;Zhao, Guoqing;Zhang, Kun;Song, Guanshui;Zhao, Baoguo. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 109-85-3 The following contents are mentioned in the article:
The direct asym. aldol reaction of glycinates represents an intriguing and straightforward strategy to make biol. significant chiral β-hydroxy-α-amino-acid derivatives But it is not easy to realize the transformation due to the disruption of the reactive NH2 group of glycinates. Inspired by the enzymic aldol reaction of glycine, we successfully developed an asym. aldol reaction of glycinate, NH2-CH2 CO-O-tert-Bu, and trifluoromethyl ketones with 0.1-0.0033 mol % of chiral N-Me pyridoxal (I) as the catalyst, producing chiral β-trifluoromethyl-β-hydroxy-α-amino-acid esters 6 in 55-82% yields (for the syn-diastereomers) with up to >20:1 dr and 99% ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymic aldol reaction of glycine. Pyridoxal catalyst I activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Related Products of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem