Proton-Mediated Practical Synthesis of McGeachin-Type Bisaminals was written by Chen, Yang;Wang, Tingting;Du, Hongguang;Xu, Jiaxi;Yang, Zhanhui. And the article was included in Synthesis in 2021.Reference of 109-85-3 The following contents are mentioned in the article:
A proton-mediated practical synthesis of McGeachin-type bisaminals I (R = R1 = H, Br, OMe; R2 = t-Bu, prop-2-en-1-yl, cyclohexyl, naphthalen-1-yl, furan-2-ylmethyl, etc.) from 2-(alkylamino)arenecarbaldehydes 2-(NHCH3)-5-RC6H3CHO and primary amines R2NH2 is achieved, with trifluoroacetic acid as the proton donor. The use of a proton, a smallest electrophilic activator, allows previously inviable ortho-substituted anilines and linear and branched aliphatic amines R2NH2 to be viable substrates for McGeachin bisaminal synthesis I. Overcoming the steric and electronic limitations provides a practical synthetic method. The applications in product derivation and pharmaceutical mol. modification are also demonstrated. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem