Ynamide-Mediated Intermolecular Esterification was written by Wang, Xuewei;Yang, Yang;Zhao, Yongli;Wang, Sheng;Hu, Wenchang;Li, Jinmei;Wang, Zihao;Yang, Fengling;Zhao, Junfeng. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C13H12O2 The following contents are mentioned in the article:
An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Electric Literature of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem