Highly potent inhibitors of TNF-α production. Part I. Discovery of new chemical leads and Their structure-Activity relationships was written by Matsui, Toshiaki;Kondo, Takashi;Nishita, Yoshitaka;Itadani, Satoshi;Nakatani, Shingo;Omawari, Nagashige;Sakai, Masaru;Nakazawa, Shuichi;Ogata, Akihito;Mori, Hideaki;Terai, Kouichiro;Kamoshima, Wataru;Ohno, Hiroyuki;Obata, Takaaki;Nakai, Hisao;Toda, Masaaki. And the article was included in Bioorganic & Medicinal Chemistry in 2002.COA of Formula: C9H14ClNO2 The following contents are mentioned in the article:
Discovery of new chem. leads of inhibitors for TNF-α production starting from the chem. modification of 2-(octanoylamino)-2-phenylethyl disodium phosphate (I) is reported. Further biol. studies of I to disclose the site of its action strongly suggested that I inhibits LPS-induced TNF-α expression in the liver and spleen of mice. Structure-activity relationships (SARs) are also discussed and full details including the chem. are reported. This study involved multiple reactions and reactants, such as (R)-2-Amino-2-(3-methoxyphenyl)ethanol hydrochloride (cas: 532987-19-2COA of Formula: C9H14ClNO2).
(R)-2-Amino-2-(3-methoxyphenyl)ethanol hydrochloride (cas: 532987-19-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H14ClNO2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem