Bioorganic & Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.
Katoh, Takahiro published the artcileSynthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase, Related Products of ethers-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2007), 15(7), 2736-2748, database is CAplus and MEDLINE.
DL-Standishinal (I), an aromatase inhibitor isolated from Thuja standishii, was synthesized in 15 steps from p-formylanisole via an acid catalyzed aldol reaction of (±)-12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-dial (II). It was found that the aldol condensation of II proceeded in excellent yield with the protonic catalyst such as d-camphorsulfonic acid in CH2Cl2. Moreover, structure-activity relationship of I and its related compounds, such as (±)-O-methylferruginol (III), was studied, and it was revealed that the isomers having cis-configuration on the A/B-ring generally exhibited more potent inhibitory activities against aromatase than those with trans-configuration.
Bioorganic & Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem