Catalytic Lewis and Bronsted acid syn-diastereoselective benzylic substitutions of α-hydroxy-β-nitro- and α-hydroxy-β-azido-alkyl arenes was written by Hensienne, Raphael;Cusson, Jean-Philippe;Chenard, Etienne;Hanessian, Stephen. And the article was included in Canadian Journal of Chemistry in 2020.Computed Properties of C13H12O2 The following contents are mentioned in the article:
A series of alkyl and alkenyl p-methoxy arenes containing α,β-disubstituted diamino and amino alc. groups were synthesized from β-nitro and β-azido benzylic alcs. in the presence of AuCl3 as catalyst. The formation of predominantly syn-disubstituted products were rationalized on the basis of mechanistic considerations and transition state models relying on A1,3-allylic strain. The products could have utility in the design of medicinally relevant compounds and as chiral ligands for asym. catalysis. A new synthesis of (+)-sertraline (Zoloft) was achieved. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem