Palladium-Catalyzed Cascade Carbonylation to α,β-Unsaturated Piperidones via Selective Cleavage of Carbon-Carbon Triple Bonds was written by Ge, Yao;Ye, Fei;Yang, Ji;Spannenberg, Anke;Jiao, Haijun;Jackstell, Ralf;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2021.HPLC of Formula: 109-85-3 The following contents are mentioned in the article:
A direct and selective synthesis of α,β-unsaturated piperidones by a new palladium-catalyzed cascade carbonylation is described. In the presented protocol, easily available propargylic alcs. react with aliphatic amines to provide a broad variety of interesting heterocycles. Key to the success of this transformation is a remarkable catalytic cleavage of the present carbon-carbon triple bond by using a specific catalyst with 2-diphenylphosphinopyridine as ligand and appropriate reaction conditions. Mechanistic studies and control experiments revealed branched unsaturated acid as crucial intermediate. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3HPLC of Formula: 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem