Electrooxidative and Regioselective C-H Azolation of Phenol and Aniline Derivatives was written by Feng, Pengju;Ma, Guojian;Chen, Xiaoguang;Wu, Xing;Lin, Ling;Liu, Peng;Chen, Tianfeng. And the article was included in Angewandte Chemie, International Edition in 2019.Synthetic Route of C13H12O2 The following contents are mentioned in the article:
A general and practical protocol was developed for the regioselective C-H azolation of phenol and aniline derivatives by electrooxidative cross-coupling [e.g., 4-methoxyphenol + pyrazole → 4-methoxy-2-(1H-pyrazol-1-yl)phenol (97%)]. The reaction occurs under metal-, oxidant-, and reagent-free conditions, allowing access to a wide variety of synthetically useful heteroarene derivatives The reaction also tolerates a broad range of functional groups and is amenable to gram-scale synthesis. Finally, a preliminary mechanistic study indicated that a radical-radical-combination pathway might be involved in the coupling reaction. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C13H12O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem