Studies towards the conception of new selective PPARβ/δ ligands was written by Ekambome Bassene, Carine;Suzenet, Franck;Hennuyer, Nathalie;Staels, Bart;Caignard, Daniel-Henri;Dacquet, Catherine;Renard, Pierre;Guillaumet, Gerald. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Synthetic Route of C14H14O2 The following contents are mentioned in the article:
In order to define new PPARβ/δ ligands, SAR study on the selective PPARβ/δ activator L-165,041 led to the identification of one key functional group for selective PPARβ/δ activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARβ/δ ligand GW501516, the conception of new ligands showing good affinity for PPARβ/δ is reported. Finally, synthesis and biol. evaluation of pyridine analogs have shown the beneficial effect of the pyridine ring on the PPARβ/δ subtype selectivity. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Synthetic Route of C14H14O2).
4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C14H14O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem