Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction was written by Chen, Wei-Jin;Yuan, Gao-Qing. And the article was included in Tetrahedron Letters in 2022.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:
An efficient electrochem. synthesis of 1,2,3-trisubstituted pyrroles I (R1 = n-Pr, Bn, cyclohexyl, etc.; R2 = H, Ph, Bn, i-Pr, etc.; R3 = Me, OMe, OEt, OPr, Ph) was developed by one-pot three-component reaction of β-dicarbonyl compounds, R3C(O)CH2C(O)CH3 aldehydes R2CH2CHO with amines R1NH2. The target products could be obtained in good to excellent yields. The investigations indicate that β-enamino ketone is a key intermediate in this transformation and the reaction mechanism may involve a radical addition reaction pathway. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of 2-Methoxyethylamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem