Mild Base-Promoted Tandem Nucleophilic Substitution/Decarboxylation/Hydroamination: Access to 3-Sulfonylindoles and 2-Methyleneindophenols was written by Chen, Guifang;Xu, Bo. And the article was included in Organic Letters in 2021.Recommanded Product: 103-16-2 The following contents are mentioned in the article:
An efficient construction of 3-sulfonylindoles and 2-methyleneindophenols via decarboxylative propargylation/hydroamination of ethynyl benzoxazinanones using sodium sulfonates and phenols as the nucleophiles was developed. The reaction featured mild conditions (K2CO3), simple operation, and high chemoselectivity and was transition-metal-free. The present protocol could also be extended to other nucleophiles, including malonates, alcs., and indoles. The broad substrate scope and scalability made this protocol practical for the synthesis of indole derivatives This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).
4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 103-16-2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem