Controlled copolymerization of α-NCAs and α-NNTAs for preparing peptide/peptoid hybrid polymers with adjustable proteolysis was written by Zou, Jingcheng;Zhou, Min;Ji, Zhemin;Xiao, Ximian;Wu, Yueming;Cui, Ruxin;Deng, Shuai;Liu, Runhui. And the article was included in Polymer Chemistry in 2022.Computed Properties of C3H9NO The following contents are mentioned in the article:
Peptides and polypeptides have excellent biocompatibility and numerous biol. functions; however, their application is restricted by their proneness to proteolytic degradation Although the incorporation of peptoid residues into peptides can improve their stability against proteases, the synthesis of peptide/peptoid hybrid oligomers suffers from the tedious and time consuming solid-phase synthesis process. Hereby, the authors report a living and controlled copolymerization of α-amino acid N-carboxyanhydrides (α-NCAs) and N-substituted α-amino acid N-thiocarboxyanhydrides (α-NNTAs) for the facile synthesis of peptide/peptoid hybrid polymers with an alternating-like distribution of residues, controllable mol. weight and narrow dispersity. Moreover, this polymerization strategy enables quick synthesis of peptide mimicking peptide/peptoid hybrid polymers with adjustable proteolysis by varying the proportion of peptoid residues. Our studies shed some light on the facile synthesis of peptide mimicking peptide/peptoid hybrid polymers with tunable proteolysis and open new avenues for preparing novel peptide mimics with tunable proteolysis and large structural diversity. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem