After enjoying curry: urine metabolism analysis of curcuminoids by microemulsion electrokinetic chromatography with laser-induced native fluorescence detection was written by Zang, Kun;Xia, Jingtong;Wu, Chengxin;Yang, Shuping;Wang, Wei;Zeng, Zhi-Cong;Zhou, Lei;Pu, Qiaosheng. And the article was included in Journal of Chromatography A in 2021.Formula: C19H16O4 The following contents are mentioned in the article:
Considering pH-dependent fluorescence of curcuminoids, a microemulsion electrokinetic chromatog. (MEEKC) method was developed under acidic conditions for their separation and detection using laser-induced native fluorescence (LINF), so as to solve the anal. of urine metabolism for curcuminoids. The microemulsion composition was optimized by response surface methodol. (RSM), and the effects of buffer pH and organic modifiers were systematically investigated. The optimal buffer for the separation of curcuminoids was chosen as follows: 2.8% (volume/volume) Et acetate, 80 mM SDS and 2.8% (volume/volume) n-butanol to form microemulsion, 28% (volume/volume) ethanol as organic modifier, and 20 mM phosphoric acid as electrolyte at pH 3.0. Under these conditions, four curcuminoids including curcumin, demethoxy curcumin (DMC), bisdemethoxy curcumin (BDMC) and demethyl curcumin (DEC) could be well separated within 18 min, and the detection limits (LOD, based on S/N=3) were calculated to be 71, 60, 22, and 147 pg mL-1, resp. Combined with solid-phase extraction (SPE), the developed MEEKC-LINF method has been successfully applied to continuously monitor the curcuminoids and related metabolites in human urine collected from a healthy volunteer after oral administration of curry, testifying that this method has potential for evaluating the pharmacol. activity of curcuminoids. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem