Therapeutic deep eutectic solvent-based microemulsion enhances anti-inflammatory efficacy of curcuminoids and aromatic-turmerone extracted from Curcuma longa L. was written by Supaweera, Nassareen;Chulrik, Wanatsanan;Jansakun, Chutima;Bhoopong, Phuangthip;Yusakul, Gorawit;Chunglok, Warangkana. And the article was included in RSC Advances in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:
To diminish chem. waste and improve the delivery of Curcuma longa L. (CL) constituents, microemulsions based on hydrophobic deep eutectic solvents (HDESs) were designed as ready-to-use solvents for CL extraction The microemulsion (ME) of the ME-23 formulation (HDES/Tween 80 : propylene glycol (1 : 1)/water, 25/70/5) displayed CL extraction yields of 1.69, 3.04, 7.36, and 1.39 wt% of bisdemethoxycurcumin, demethoxycurcumin, curcumin, and aromatic-turmerone, resp. The ME-23 without CL chem. constituents and ME-23-based CL extract inhibited NO production with an IC50 value of 0.0136 ± 0.0023%volume/volume and a curcumin IC50 value of 75.2 ± 6.7 nM, resp., and simultaneously lowered inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1β production in lipopolysaccharide-activated murine macrophages. Authentic curcumin in ME-23 possessed superior NO inhibitory activity, which was 103-fold more effective than curcumin prepared in the conventional solvent DMSO. ME-23 was also capable of delivering curcumin into murine macrophages. After 30 days of storage in HDES and HDES-based ME, curcumin remained more than 90%. ME-23 provides advantages for CL extraction, constituent delivery, and anti-inflammatory functions that can be applied to pharmaceutical and cosmetic products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 33171-05-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem