Preparation and antimicrobial activities of new piperidine substituted benzothiazole derivatives was written by Shafi, S. Syed;Rajesh, R.;Subaash, R.;Gopinath, S.. And the article was included in Heterocyclic Letters in 2021.Electric Literature of C3H9NO The following contents are mentioned in the article:
Synthesis of piperidine substituted benzothiazole derivatives I [R = 1-piperidyl, (2-methoxyethylamino), (4-bromoanilino), etc.] was reported. The synthesis was done by the reaction of Et 2-aminobenzo[d]thiazole-6-carboxylate with copper (II) bromide followed by the addition of piperidine and get Et 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylate. The reaction of Et 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylate with NaOH produced 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylic acid. The intermediate 2-(piperidin-1-yl)benzo[d]thiazole-6-caroxylic acid was isolated as stable compounds The chem. structures of synthesized compounds were established based on spectral data of 1H-NMR, 13C-NMR, and IR. The mass of the novel compounds was established with the help of the LCMS test. The biol. studies of synthesized compounds I showed that the piperidine, amine, and bromine substituted aniline substituted compounds had good antibacterial activity. The compound amine substituted compound exhibited good antifungal activity. The formation of the crystal was confirmed by powder XRD and the average crystalline size was 54 nm. The photoluminescence data explain the optical property of the compound The biol. studies of synthesized compounds showed that compound I [R = 4-bromoanilino] possesses good antibacterial activity and compound I [R = 2-methoxyethylamino] had good antifungal activity. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Electric Literature of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C3H9NO
Referemce:
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Ether | (C2H5)2O – PubChem