Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity was written by Pettinari, Riccardo;Marchetti, Fabio;Tombesi, Alessia;Duan, Fenghe;Zhou, Liming;Messori, Luigi;Giacomelli, Chiara;Marchetti, Laura;Trincavelli, Maria Letizia;Marzo, Tiziano;La Mendola, Diego;Balducci, Gabriele;Alessio, Enzo. And the article was included in Journal of Inorganic Biochemistry in 2021.Computed Properties of C19H16O4 The following contents are mentioned in the article:
Two cationic ruthenium(II) 1,4,7-trithiacyclononane ([9]aneS3) complexes of curcumin (curcH) and bisdemethoxycurcumin (bdcurcH), namely [Ru(curc)(DMSO-S)([9]aneS3)]Cl (1) and [Ru(bdcurc)(DMSO-S)([9]aneS3)]Cl (2) were prepared from the [RuCl2(DMSO-S)([9]-aneS3)] precursor and structurally characterized, both in solution and in the solid state by x-ray crystallog. The corresponding PTA complexes [Ru(curc)(PTA)([9]aneS3)]Cl (3) and [Ru(bdcurc)(PTA)([9]aneS3)]Cl (4) were also synthesized and characterized (PTA = 1,3,5-triaza-7-phosphaadamantane). Bioinorganic studies relying on mass spectrometry were performed on complexes 1–4 to assess their interactions with the model protein lysozyme. Overall, a rather limited reactivity with lysozyme was highlighted accompanied by a modest cytotoxic potency against three representative cancer cell lines. The moderate pharmacol. activity is likely connected to the relatively high stability of these complexes. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Computed Properties of C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem