Study of concentration dependent curcumin interaction with serum biomolecules using ATR-FTIR spectroscopy combined with Principal Component Analysis (PCA) and Partial Least Square Regression (PLS-R) was written by Perera, Kalindu D. C.;Weragoda, Geethika K.;Haputhanthri, Rukshani;Rodrigo, Sanjeewa K.. And the article was included in Vibrational Spectroscopy in 2021.Product Details of 33171-05-0 The following contents are mentioned in the article:
The binding of curcumin with biomols. in biol. fluids can affect the activity, distribution, rate of excretion, and toxicity of pharmaceutical agents in the body. It is said that interaction of curcumin with bio mols. such as protein can increase its bioavailability. A simpler alternative to current methods for study of curcumin interaction with biomols. in biol. fluids and the quantification of the interacted curcumin is therefore useful. Herein we demonstrated a method based on ATR-FTIR spectroscopy combined with multivariate anal. for concentration dependent curcumin interaction with serum biomols. as a model. ATR-FTIR spectra of curcumin-spiked serum samples were acquired and data were processed with two different multivariate methods namely, Principal Component Anal. (PCA) and Partial Least-Squares Regression (PLS-R). PCA of the protein region (1701-1304 cm-1) shows a separation into groups based on the concentration of curcumin with no overlaps indicating the curcumin interaction is highest with serum proteins other than lipids and carbohydrates. PLS-R was employed to construct a calibration plot in carbohydrate, protein and lipid regions. The limit of detection of the interaction for all three regions was 10 ppm. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Product Details of 33171-05-0).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 33171-05-0
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem