Quality assessment and RP-HPLC method development for estimation of curcuminoids in Curcuma longa: A Quality by Design approach was written by Parab Gaonkar, Vishakha;Hullatti, Kirankumar. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2021.Application In Synthesis of Bisdemethoxycurcumin The following contents are mentioned in the article:
The present work aims at developing a QbD assisted RP-HPLC method for the estimation of individual curcuminoids in Curcuma longa rhizomes along with its quality assessment. The quality of crude C. longa sample was evaluated with respect to physicochem., phytochem. and toxic contaminant anal. The ATP and CQA’s were identified followed by the optimization of the method by employing 22 factorial design. The concentration of orthophosphoric acid in aqueous phase (X1) and mobile phase ratio (X2) were selected as independent variable whereas, Tailing factor CUR (R1), peak width CUR (R2), Tailing factor DMC (R3), peak width DMC (R4), Tailing factor BDC (R5), and peak width BDC (R6) selected as dependent variables. The optimized chromatog. conditions were identified with mobile phase, Acetonitrile and Water (0.02%OPA) in the ratio of 55:44 with flow rate of 1 mL/min and detection wavelength of 425 nm. Further, the amount of curcumin, demethoxycurcumin and bis-demethoxycurcumin in crude C. longa sample was found to be 13.86±0.28, 10.98±0.23 and 9.32±0.20 mg/g resp. From the results obtained it can be concluded that the application of the QbD approach ensured the development of a more precise method that can engender consistent, reliable, and quality data throughout the process and also save time. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application In Synthesis of Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem