Nikolova, Ivanka et al. published their research in Bioorganic Chemistry in 2019 | CAS: 103-16-2

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 103-16-2

Anti-enteroviral activity of new MDL-860 analogues: synthesis, in vitro/in vivo studies and QSAR analysis was written by Nikolova, Ivanka;Slavchev, Ivaylo;Ravutsov, Martin;Dangalov, Miroslav;Nikolova, Yana;Zagranyarska, Irena;Stoyanova, Adelina;Nikolova, Nadya;Mukova, Lucia;Grozdanov, Petar;Nikolova, Rosica;Shivachev, Boris;Kuz’min, Victor E.;Ognichenko, Liudmila N.;Galabov, Angel S.;Dobrikov, Georgi M.. And the article was included in Bioorganic Chemistry in 2019.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

A series of 60 nitrobenzonitrile analogs of the anti-viral agent MDL-860 were synthesized (50 of which are new) and evaluated for their activity against three types of enteroviruses (coxsackievirus B1, coxsackievirus B3 and poliovirus 1). Among them, six diaryl ethers (20e, 27e, 28e, 29e, 33e and 35e) demonstrated high in vitro activity (SI > 50) towards at least one of the tested viruses and very low cytotoxicity against human cells. Compound 27e, 2-(2,5-difluorophenoxy)-5-nitrobenzonitrile(I), possesses the broadest spectrum of activity towards all tested viruses in the same way as MDL-860 does. The most active derivatives (I), 29e 2-(2-chloro-5-fluorophenoxy)-5-nitrobenzonitrile (II) and 35e 2-(3,4-Dibromophenoxy)-5-nitrobenzonitrile(III) against coxsackievirus B1 were tested in vivo in newborn mice exptl. infected with 20 MLD50 of coxsackievirus B1. II showed promising in vivo activity (protection index 26% and 4 days lengthening of mean survival time). QSAR anal. of the substituent effects on the in vitro cytotoxicity (CC50) and anti-viral activity of the nitrobenzonitrile derivatives was carried out and adequate QSAR models for the anti-viral activity of the compounds against poliovirus 1 and coxsackievirus B1 were constructed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem