TOF-SIMS analysis of curcuminoids and curcumin crystals crystallized from their pure and impure solutions was written by Kumar, K. Vasanth;Heffernan, Claire;Ramisetty, Kiran A.;Howard, Christopher A.;Beloshapkin, Sergey. And the article was included in CrystEngComm in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:
Impurities are frequently encountered during the crystallization of active pharmaceutical compounds Impurities can either adsorb onto active sites or replace atoms of the crystal lattice. Locating the impurities, especially structurally-similar impurities, on the crystal surface is challenging. In this work, we showed that time-of-flight secondary ion mass spectrometry (TOF-SIMS) can be successfully used to simultaneously quantify the composition of the two structurally-similar impurities, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), on the surface of the curcumin (CUR) crystals obtained from crystal growth and cooling crystallization experiments The distribution of the three curcuminoids on the crystal surface was evaluated through imaging of the specific ions that correspond to intact mols. of the curcuminoids. In terms of location, both BDMC and DMC were evenly distributed on the surfaces of the facets of the curcumin crystals. Addnl., we found that BDMC and DMC occupy their own sites or they are located on the same site on the crystal surface providing evidence for lattice replacement of these mols. Thus our results demonstrate the potential of TOF-SIMS to provide new information that can help to understand crystallization This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem