Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives was written by Huang, Wenbo;Gao, Zilin;Zhang, Zhigang;Fang, Wei;Wang, Zuoqian;Wan, Zhongyi;Shi, Liqiao;Wang, Kaimei;Ke, Shaoyong. And the article was included in Bioorganic Chemistry in 2021.Reference of 109-85-3 The following contents are mentioned in the article:
The aim of this article was to explore new chem. entities containing carbazole scaffold as potential novel cytotoxic agents based on our developed three-component indole-to-carbazole reaction. Two series of carbazoles, compounds I [R1 = H, Me; R2 = cyclohexyl, 4-fluorophenyl, quinolin-8-yl, etc.] and II [R3 = H, Me; R4 = methoxyethyl, (methylsulfonyl)ethyl, 4-fluorophenethyl, etc.] were designed and synthesized, and their in-vitro cytotoxic activities against three cell lines (A875, HepG2, and MARC145) were evaluated. The results indicated that some of these carbazole derivatives exhibited significantly good cytotoxic activities against tested cell lines compared with the control 5-fluorouracil (5-FU). Especially, carbazole acylhydrazone, compounds I [R1 = H, R2 = benzodioxol-5-ylmethyl] and [R1 = Me, R2 = 4-chlorophenyl] displayed high inhibitory activity on cancer cells, but almost no activity on normal cells. Further anal. of induced apoptosis for potential compounds indicated that the potential antitumor agents induced cell death in A875 cells at least partly (initially) by apoptosis, which might be used as promising lead scaffold for discovery of novel carbazole-type cytotoxic agents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem