Disposition of Dietary Polyphenols in Breast Cancer Patient’s Tumors, and Their Associated Anticancer Activity: The Particular Case of Curcumin was written by Avila-Galvez, Maria Angeles;Gonzalez-Sarrias, Antonio;Martinez-Diaz, Francisco;Abellan, Beatriz;Martinez-Torrano, Alejandro Jose;Fernandez-Lopez, Antonio Jose;Gimenez-Bastida, Juan Antonio;Espin, Juan Carlos. And the article was included in Molecular Nutrition & Food Research in 2021.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:
Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) and malignant (MT) mammary tissues of newly-diagnosed BC patients and the tissue-occurring metabolite’s anticancer activity are evaluated. Patients (n = 26) consumed 3 capsules/day (turmeric, red clover, and flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from biopsy-confirmed diagnosis to surgery (5 ± 2 days) or did not consume capsules (n = 13). NT and MT, blood, and urine are analyzed by UPLC-QTOF-MS using targeted metabolomics. Anticancer activity was tested in MCF-7 and MDA-MB-231 BC cells. Mainly phase-II metabolites were detected (108, 84, 49, and 47 in urine, plasma, NT, and MT, resp.). Total metabolite concentrations reached 10.7 ± 11.1 and 2.5 ± 2.4μmol L-1 in NT and MT, resp. Free curcumin, but not its glucuronide, was detected in the tissues (1.1 ± 1.8 and 0.2 ± 0.2μmol L-1 in NT and MT, resp.). Breast tissue-occurring metabolite’s antiproliferation was mainly exerted in p53-wild-type MCF-7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone-derived metabolites exerted estrogenic-like activity. Curcuminoids could be coadjuvants that might help fight BC upon regular consumption. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Bisdemethoxycurcumin
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Ether | (C2H5)2O – PubChem