Validation of a gas chromatography-mass spectrometry isotope dilution method for the determination of 2-butoxyethanol and other common glycol ethers in consumer products was written by Tokarczyk, Ryszard;Jiang, Ying;Poole, Gary;Turle, Richard. And the article was included in Journal of Chromatography A in 2010.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:
A gas chromatog.-mass spectrometry isotope dilution (GC-MS ID) method was developed and tested for the determination of 14 common glycol ethers in consumer products. Stable isotope labeled standards, 2-methoxyethanol-D7 and 2-butoxyethanol-13C2 (CDN isotopes) were employed to enhance the accuracy and precision of the glycol ethers determination A 1000-fold sample dilution with methanol was applied to avoid column overload and contamination. At this dilution matrix effects were in most cases negligible and did not interfere with the anal. The instrument detection limit (IDL) for analyzed compounds varied from 0.01 to 1 μg/mL; while the estimated limit of quantification (LoQ) varied between different glycol ethers from 0.02 to 3.4 μg/mL. Calibration was tested at 0.1-200 μg/mL and showed that the linear fit is upheld from 0.1 to 10 μg/mL, and extends beyond this range for some of the analytes. Recoveries of glycol ethers from products with different matrixes were similar. The recoveries varied from 87% to 116% between the analyzed compounds, while measurements precision varied between 2% and 14%. The method is applicable to products with glycol ether concentrations >0.002-0.2% (weight/weight). The concentration range can be extended below the specified limits by decreasing the dilution factor; however, with lower dilution the sample matrix effect is expected to be stronger. Products with very high concentrations of glycol ether (>20%) may need to be further diluted prior to injection to avoid column overload. The method can be used for testing liquid and aerosol products designed for household use, such as cleaners, paints, solvents and paint strippers, for compliance and enforcement of regulations which limit glycol ethers content. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol).
2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem