Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions was written by Kothaplly, Sudhakar;Alukapally, Shankar;Nagula, Nagaraju;Maddela, Rambabu. And the article was included in Advances in Therapy in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:
Despite its broad range of biol. activities, use of curcumin is limited because of poor bioavailability. Here we report a novel curcumin formulation, Curcuwin Ultra+ (CU+), with superior bioavailability as compared to 95% turmeric extract (TUR 1800). A randomized, double-blind, three-treatment, crossover oral bioavailability study was conducted in 24 healthy volunteers under fasting conditions. Subjects received a single dose of CU+ 250 mg, 500 mg and 1900 mg of TUR1800 as per randomization schedule and blood samples were collected at 4 h and 0 h before dosing, and 0.5, 1, 2, 3, 4, 5, 6, 8, 10, 12, 24 h post dose. Total curcuminoids were measured as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and tetrahydrocurcumin using a validated LC-MS/MS method. CU+ achieved a significantly higher (p < 0.05) maximum plasma concentration (Cmax) and total systemic exposure (AUC0-6 and AUC0-12) for total curcuminoids as compared to TUR 1800. We observed 101 and 100 times higher Cmax resp. for 250 and 500 mg doses of CU+ as compared to 1900 mg of TUR1800. Similarly, AUC0-6 was 144 and 149 times higher whereas AUC0-12 was 99 and 113 times higher resp. for 250 and 500 mg doses of CU+ as compared to 1900 mg dose of TUR1800. Further, CU+ showed 40% faster absorption (p < 0.05). No safety issues were observed CU+, which is designed for increased absorption and protection of curcuminoids from intestinal degradation, demonstrated superior bioavailability as compared to TUR1800 at considerably smaller doses. Addnl. clin. studies will help to demonstrate the impact of its increased bioavailability on efficacy. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C19H16O4
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem