Low-surfactant microemulsion, a smart strategy intended for curcumin oral delivery was written by Dourado, Douglas;Oliveira, Matheus Cardoso de;Araujo, Guilherme Rodolfo Souza de;Amaral-Machado, Lucas;Porto, Dayanne Lopes;Aragao, Cicero Flavio Soares;Alencar, Everton do Nascimento;Egito, Eryvaldo Socrates Tabosa do. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:
This study aimed to develop a low surfactant concentration curcumin-loaded microemulsion (Curc-ME) having a gastrointestinal pH resistance, intended to prospect its oral use for further curcumin release. The effect of excipients on the apparent solubility of curcumin was assessed and a pseudo ternary phase diagram was designed to produce a low-surfactant microemulsion (ME) system. Curcumin was incorporated into the ME (Curc-ME), and the system was further physicochem. and phys. characterized. The entrapment efficiency (EE) was determined by UHPLC. The systems′ stability under storage, and its stability and curcumin release in simulated gastrointestinal fluids (SGIF) were evaluated. The excipients of the ME improved curcumin′s apparent solubility Curc-ME, stabilized with 15% of surfactants, displayed spherical droplets (sized of 21.81 ± 0.20 nm), polydispersity index of 0.07 ± 0.01, viscosity of 5.33 x 10-3 ± 0.01 Pa.s, conductivity of 160 ± 3 μS cm-1, surface tension of 40.37 ± 0.48 dynes/cm and EE of 98 ± 0.73%. Thermal analyses confirmed curcumin entrapment in the core of the system. The system remained stable over 90 days under storage and under SGIF conditions. Curc-ME revealed a modified and complex kinetics release of curcumin in the SGIF. Overall, the results demonstrate that Curc-ME increased the solubility of curcumin, was produced with a remarkable low surfactant concentration, and showed stability and modified curcumin release at the gastrointestinal tract pHs. Therefore, Curc-ME revealed to be a promising candidate to be further explored as a therapeutic agent. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).
Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Bisdemethoxycurcumin
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem