In vitro and in vivo genetic toxicology studies with diethylene glycol monohexyl ether was written by Ballantyne, Bryan;Vergnes, Jane S.. And the article was included in Journal of Applied Toxicology in 2001.Computed Properties of C10H22O3 The following contents are mentioned in the article:
Diethylene glycol monohexyl ether (DEGHE; CAS number 112-59-4), an industrial chem., was investigated for the potential to produce genotoxic effects using 3 in vitro and 2 in vivo tests. No mutagenic activity occurred in either the absence or the presence of metabolic activation with a Salmonella typhimurium reverse assay using strains TA98, TA100, TA1535, TA1537, and TA1538. In a Chinese hamster ovary (CHO) forward gene mutation test (HGPRT locus), there was an increase in the mutation frequencies, which were relatively small compared with the solvent control values, somewhat inconsistent between duplicate cultures, and occurred particularly in the presence of metabolic activation. Linear regression anal. indicated a marginally significant trend for dosage vs. mutation frequency, suggesting that DEGHE was weakly pos. in this test. A sister chromatid exchange test in CHO cells showed no significant dosage-related effects in the presence or absence of metabolic activation. A peripheral blood micronucleus test in mice by dosing with an i.p. injection of DEGHE did not show any potential for DEGHE to increase the incidence of micronucleated polychromatophilic erythrocytes. In a first femoral bone marrow chromosome aberration test in the rat by peroral dosing, DEGHE did not cause any increase in aberrations for 12- and 24-h samples with males and females or with females at 48-h sampling. However, with males at 48 h, the 2 lowest doses showed an increased number of aberrations, but not at the high doses. A repeat study in males with a larger number of doses and 24- and 48-h samples did not replicate this finding. Thus, DEGHE may have limited weak mutagenic activity in vitro but is devoid of clastogenic potential. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Computed Properties of C10H22O3).
2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C10H22O3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem