Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone was written by Alldritt, Isabelle;Whitham-Agut, Beatrice;Sipin, Miguel;Studholme, Jacob;Trentacoste, Angela;Tripp, Jennifer A.;Cappai, Maria Grazia;Ditchfield, Peter;Deviese, Thibaut;Hedges, Robert E. M.;McCullagh, James S. O.. And the article was included in Scientific Reports in 2019.SDS of cas: 2380-78-1 The following contents are mentioned in the article:
Plant-derived secondary metabolites consumed in the diet, especially polyphenolic compounds, are known to have a range of pos. health effects. They are present in circulation after ingestion and absorption and can be sequestered into cells within particular organs, but have rarely been investigated systematically in osteol. tissues. However, a small number of polyphenols and similar mols. are known to bind to bone. For example alizarin, a plant derived anthraquinone and tetracycline (a naturally occurring antibiotic), are both absorbed into bone from circulation during bone formation and are used to monitor mineralization in osteol. studies. Both mols. have also been identified serendipitously in archaeol. human bones derived from natural sources in the diet. Whether an analogus mechanism of sequestration extends to addnl. diet-derived plant-polyphenols has not previously been systematically studied. We investigated whether a range of diet-derived polyphenol-like compounds bind to bone using untargeted metabolomics applied to the anal. of bone extracts from pigs fed an acorn-based diet. We analyzed the diet which was rich in ellagitannins, extracts from the pig bones and surrounding tissue, post-mortem. We found direct evidence of multiple polyphenolic compounds in these extracts and matched them to the diet. We also showed that these compounds were present in the bone but not surrounding tissues. We also provide data showing that a range of polyphenolic compounds bind to hydroxyapatite in vitro. The evidence for polyphenol sequestration into physiol. bone, and the range and specificity of polyphenols in human and animal diets, raises intriguing questions about potential effects on bone formation and bone health. Further studies are needed to determine the stability of the sequestered mols. post-mortem but there is also potential for (palaeo)dietary reconstruction and forensic applications. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1SDS of cas: 2380-78-1).
4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 2380-78-1
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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem