On September 30, 2008, Thevenot, Paul; Cho, Jai; Wavhal, Dattatray; Timmons, Richard B.; Tang, Liping published an article.Synthetic Route of 929-37-3 The title of the article was Surface chemistry influences cancer killing effect of TiO2 nanoparticles. And the article contained the following:
Photocatalyzed titanium dioxide (TiO2) nanoparticles were shown to eradicate cancer cells. However, the required in situ introduction of UV light limits the use of such a therapy in humans. In the present study the nonphotocatalytic anticancer effect of surface-functionalized TiO2 was examined Nanoparticles bearing -OH, -NH2, or -COOH surface groups were tested for their effect on in vitro survival of several cancer and control cell lines. The cells tested included B16F10 melanoma, Lewis lung carcinoma, JHU prostate cancer cells, and 3T3 fibroblasts. Cell viability was observed to depend on particle concentrations, cell types, and surface chem. Specifically, -NH2 and -OH groups showed significantly higher toxicity than -COOH. Microscopic and spectrophotometric studies revealed nanoparticle-mediated cell membrane disruption leading to cell death. The results suggest that functionalized TiO2, and presumably other nanoparticles, can be surface-engineered for targeted cancer therapy. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Synthetic Route of 929-37-3
The Article related to titanium dioxide nanoparticle surface functional group antitumor, Pharmaceuticals: Pharmaceutics and other aspects.Synthetic Route of 929-37-3
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