Rao, L. Vaikunta; Rao, K. Tirumala; Kandepi, V. V. Krishna Mohan published an article in 2020, the title of the article was A validated RP-HPLC method for estimation of related compounds in hydroxy naproxen.Related Products of 93-04-9 And the article contains the following content:
A simple, linear gradient liquid chromatog. method (RP-HPLC) is proposed for the simultaneous estimation of related compounds in hydroxy naproxen samples. Chromatog. separation was achieved on Zorbax SB C8 (150 x 4.6) mm, 3.5 μm particle size RRLC short column and eluent A used as 0.1% volume/volume trifluoroacetic acid in water and eluent B used as acetonitrile using Agilent RRLC (UHPLC) system. The mobile phase flow rate was 1.0 mL/min and the eluted compounds were monitored at 235 nm for related substance method and assay method. The excellent resolution was obtained between hydroxy naproxen and its related compounds, which were eluted within 25 min. The performance of the method was validated with respect to ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision and robustness. The correlation coefficient(r) was > 0.995 for both the methods from linearity data and percentage of recovery is 98.0 to 102.0 for assay method and 80.0 to 120.0% for related substance method. Sensitivity of the method was found be less than 0.5 μg/mL. Peak homogeneity data for naproxen in the chromatograms from the selectivity solution obtained by use of the photodiode array detector demonstrated the specificity of the method for anal. of hydroxy naproxen in presence of the related compounds The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Related Products of 93-04-9
The Article related to hydroxy naproxen reverse phase hplc, Placeholder for records without volume info and other aspects.Related Products of 93-04-9
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem