On September 26, 2022, Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian; Cong, Hengjiang; Cheng, Hong-Gang; Shi, Liangwei; Zhou, Qianghui; Zhuang, Lin published an article.Electric Literature of 578-58-5 The title of the article was From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent. And the article contained the following:
Herein,the identification of a powerful nitrating reagent, 5-methyl-1,3-dinitro-1H-pyrazole, from the N-nitro-type reagent library constructed using a practical N-H nitration method was reported. This nitrating reagent behaved as a controllable source of the nitronium ion, enabling mild and scalable nitration of a broad range of (hetero)arenes with good functional group tolerance. Of note, this nitration method was controlled by manipulating the reaction conditions to furnish mononitrated or dinitrated product selectively. The value of this method in medicinal chem. was well established by its efficient late-stage C-H nitration of complex biorelevant mols. D. functional theory (DFT) calculations and preliminary mechanistic studies reveal that the powerfulness and versatility of this nitrating reagent were due to the synergistic “nitro effect” and “methyl effect”. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5
The Article related to arene nitropyrazole nitration, nitroarene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 578-58-5
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