Venturini, Francesco; Navarrini, Walter; Famulari, Antonino; Sansotera, Maurizio; Dardani, Patrizia; Tortelli, Vito published an article in 2012, the title of the article was Direct trifluoro-methoxylation of aromatics with perfluoro-methyl-hypofluorite.Product Details of 321-28-8 And the article contains the following content:
The reactivity of CF3OF (FTM) has been widely studied especially in halogenated olefinic systems and its use in pharmaceutical synthesis as a mild radical and electrophilic fluorinating agent is well documented. On the other hand, the chem. behavior of the perfluoromethyl hypofluorite with aromatic substrates is much less studied. Up to now few and scattered data regarding its use as electrophilic fluorinating agent of variously substituted aromatic compounds are found in the literature. In this work the reactivity of CF3OF with simple electron rich and electron poor aromatics (α,α,α-trifluorotoluene, toluene, benzene, chlorobenzene, methoxybenzene) has been investigated. The possibility of selectively bind the trifluoromethoxy group (via radical mechanism) or the fluorine atom (via electrophilic addition) by varying the reaction conditions has been explored. In particular we have observed that the trifluoromethoxy free radical substitution can be the main synthetic pathway if the reaction is promoted by an independent and steady source of CF3O radical. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8
The Article related to direct trifluoromethoxylation aromtic compound perfluoromethyl hypofluorite, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Product Details of 321-28-8
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