On October 18, 2018, Trzoss, Lynnie; Betancort, Juan Manuel; Kanouni, Toufike; Wallace, Michael Brennan; Boloor, Amogh published a patent.Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The title of the patent was Preparation of N-containing heteroaryl pyridone compounds as selective CREB-binding protein inhibitors for treatment of cancer, immune disorders, and inflammatory diseases. And the patent contained the following:
The present embodiments relate to substituted heterocyclic derivatives of formula I, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Compounds of I [wherein X = N or CR7; R7 = H, halo, alkyl, or alkoxy; R2 = H, alkyl, (hetero)aryl, etc.; R5 = H, halo, CN, (un)substituted aryl, etc.; R6 = H, halo, CN, heteroaryl, etc.; R8 = (un)substituted heteroaryl] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signaling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CREB-binding protein (CBP) compared with BRD4. Exemplified I were evaluated for CBP inhibitory activity with some compounds demonstrating IC50 values of ≥ 0.5 μM (data provided). The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
The Article related to heteroarylpyridone preparation creb binding protein cancer inflammation immune disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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Ether | (C2H5)2O – PubChem