On September 11, 2013, Ricci, Paolo; Kramer, Katrina; Cambeiro, Xacobe C.; Larrosa, Igor published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was Arene-Metal π-Complexation as a Traceless Reactivity Enhancer for C-H Arylation. And the article contained the following:
Current approaches to facilitate C-H arylation of arenes involve the use of either strongly electron-withdrawing substituents or directing groups. Both approaches require structural modification of the arene, limiting their generality. We present a new approach where C-H arylation is made possible without altering the connectivity of the arene via π-complexation of a Cr-(CO)3 unit, greatly enhancing the reactivity of the aromatic C-H bonds. We apply this approach to monofluorobenzenes, highly unreactive arenes, which upon complexation become nearly as reactive as pentafluorobenzene itself in their couplings with iodoarenes. DFT calculations indicate that C-H activation via a concerted metalation-deprotonation transition state is facilitated by the predisposition of C-H bonds in (Ar-H)-Cr-(Co)3 to bend out of the aromatic plane. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene
The Article related to arene metal pi complexation traceless reactivity enhancer ch arylation, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene
Referemce:
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Ether | (C2H5)2O – PubChem