On December 17, 2021, Khan, Jabir; Tyagi, Aparna; Yadav, Naveen; Mahato, Rina; Hazra, Chinmoy K. published an article.Formula: C8H10O2 The title of the article was Lambert Salt-Initiated Development of Friedel-Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles. And the article contained the following:
Herein, a mild metal-free and efficacious route for the synthesis of biol. important 3-aryl oxindole derivatives I [R = H, OH, 4-MeOC6H4, etc.; R1 = H, Me, Br, etc.; R2 = H, NO2, Cl; R3 = H, Me, Bn, Ts; Ar = 4-HOC6H4, 2,4,6-tri-MeOC6H2, 1H-indol-3-yl, etc.] was described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, sym./unsym. double-arylated products and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeded via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized sym./unsym. 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks was further illustrated. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Formula: C8H10O2
The Article related to aryl oxindole preparation, isatin arene nucleophile hydroarylation lambert salt initiated, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C8H10O2
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