Ye, Yibin; Cheung, Kelvin Pak Shing; He, Lisi; Tsui, Gavin Chit published an article in 2018, the title of the article was Domino cyclization/trifluoromethylation of 2-alkynylanilines using fluoroform-derived CuCF3: synthesis of 3-(trifluoromethyl)indoles.Related Products of 157869-15-3 And the article contains the following content:
By employing easily accessible 2-alkynylanilines and the well-established fluoroform-derived CuCF3 reagent, a novel class of 3-(trifluoromethyl)indoles could be synthesized in good yields with no ambiguity of the CF3 position. The method utilized a domino cyclization/trifluoromethylation strategy to construct the indole cores with the concomitant installation of the CF3 group. The ultimate source of CF3 is the low-cost industrial byproduct fluoroform (CF3H). The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Related Products of 157869-15-3
The Article related to tosyl trifluoromethyl indole preparation, alkynyl aniline preparation copper trifluoromethane regioselective trifluoromethylation cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 157869-15-3
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