On January 31, 2021, Wang, Dan; Wang, Shi-Chao; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published an article.Category: ethers-buliding-blocks The title of the article was Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3-Naphthylated Indoles from β-Alkynyl Ketones and o-Alkynyl Anilines. And the article contained the following:
A new dual palladium/scandium catalysis starting from β-alkynyl ketones and o-alkynyl anilines was reported for the first time, leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles I [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = H, 6-F, 7-Me; R3 = cyclopropyl, Ph, 2-naphthyl, etc.; R4 = H, 5-Me, 5-Cl] in moderate to good yields and high regioselectivity. This method could tolerate normal air conditions, and featured the use of palladium/scandium cooperative catalysts without any ligand, facile double annulation involving various internal alkynes, and good functional group tolerance. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Category: ethers-buliding-blocks
The Article related to rotationally hindered c3 naphthylated indole regioselective preparation, ketone alkynyl aniline double annulation palladium catalyst scandium, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: ethers-buliding-blocks
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