Salamanca, Vanesa; Albeniz, Ana C. published an article in 2021, the title of the article was Faster palladium-catalyzed arylation of simple arenes in the presence of a methylketone: beneficial effect of an a priori interfering solvent in C-H activation.Electric Literature of 91-16-7 And the article contains the following content:
The arylation of arenes with no directing groups (non-chelate assisted) was carried out using the cooperating ligand [2,2′-bipyridin]-6(1H)-one (bipy-6-OH), the use of a moderately coordinating solvent allows a decrease of the amount of arene used. Moreover, for the least coordinating arenes, the co-solvent produced a significant accelerating effect by altering the concentration and relative stability of relevant metal species in the catalytic cycle as well as the catalyst resting state. t-Bu Me ketone (pinacolone) was one of the most effective co-solvents: Even if the ketone C-H bond cleaves easily, the final products were determined by the reductive elimination step (the product-forming step) so the target biaryl products were selectively observed The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Electric Literature of 91-16-7
The Article related to arene haloarene palladium catalyst regioselective arylation, biaryl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Electric Literature of 91-16-7
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