Garcia-Gonzalez, Ma. Carmen; Hernandez-Vazquez, Eduardo; Gordillo-Cruz, Raul E.; Miranda, Luis D. published an article in 2015, the title of the article was Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles.SDS of cas: 887581-09-1 And the article contains the following content:
Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacol. important polyheterocyclic systems through a cascade palladium-catalyzed C-C bond formation processes (tandem reaction). Allyl, homoallyl and propargyl amine led to the formation of benzopyrrolizidinone derivatives, benzoindolizidinone derivatives and pyrazinoisoquinoline derivatives, resp., while benzylamines and o-bromobenzylamine were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindione derivatives Under optimized conditions the synthesis of the target compounds was achieved using dichlorobis(triphenylphosphine)palladium as a catalyst. Starting materials included 2-propen-1-amine (allyl amine), 2-iodobenzoic acid derivatives 2-bromobenzoic acid derivatives, 2-(benzoyloxy)acetaldehyde, isocyanides (isonitriles), 3-buten-1-amine (homoallyl amine). Dehydro amino acid amides (dehydroalanine derivatives) intermediates included N-[1-[[(1,1-dimethylethyl)amino]carbonyl]ethenyl]-2-iodo-N-(phenylmethyl)benzamide, thiophene derivatives, furan derivatives, pyrrole derivatives, indole derivatives The title compounds thus formed included (methylene)(oxo)pyrrolo[2,1-a]isoindolecarboxamides, (methylene)(oxo)pyrido[2,1-a]isoindolecarboxamides, isoindolo[2,1-b]isoquinolinecarboxamides, pyrazino[1,2-b]isoquinolinedione derivatives. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).SDS of cas: 887581-09-1
The Article related to benzopyrrolizidinone benzoindolizidinone pyrazinoisoquinoline pyrazionoisoquinolindione preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 887581-09-1
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